Justice League: A Better World
Central City, Missouri
Central City, Missouri, located across the Missouri River from Keystone City, Kansas, was founded in the 19th century and became an important stop for cattle drives. It began to see tremendous growth after the completion of the Transcontinental Railroad, becoming the first major hubs west of Chicago. A second period of growth occurred after World War I, and it has burgeoned to the present day. Central City was the home to the second Flash.
Star Labs Central City Facility is located in Central City.
DC HEROES RPG 3rd Edition p.150
DC Wikia entry